Thierry Frébourg Selected Research

Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)

5/2017	Neuron-to-Neuron Transfer of FUS in Drosophila Primary Neuronal Culture Is Enhanced by ALS-Associated Mutations.
5/2012	Accumulation of insoluble forms of FUS protein correlates with toxicity in Drosophila.
2/2011	Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies.

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Thierry Frébourg Research Topics

Disease

19	Neoplasms (Cancer) 01/2018 - 02/2002
9	Colorectal Neoplasms (Colorectal Cancer) 09/2015 - 03/2002
5	Alzheimer Disease (Alzheimer's Disease) 12/2021 - 05/2005
4	Sarcoma (Soft Tissue Sarcoma) 01/2018 - 05/2010
4	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 05/2017 - 07/2008
3	Breast Neoplasms (Breast Cancer) 01/2018 - 03/2009
3	Ovarian Neoplasms (Ovarian Cancer) 12/2017 - 06/2011
3	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 05/2017 - 02/2011
3	Microsatellite Instability 01/2013 - 04/2004
2	Hereditary Nonpolyposis Colorectal Neoplasms (Hereditary Nonpolyposis Colorectal Cancer) 09/2015 - 04/2004
2	Intellectual Disability (Idiocy) 04/2014 - 09/2009
2	Tauopathies 05/2010 - 10/2006
2	Carcinoma (Carcinomatosis) 05/2010 - 05/2010
2	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 01/2010 - 10/2007
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2010 - 03/2003
2	Schizophrenia (Dementia Praecox) 09/2009 - 03/2006
1	Uniparental Disomy 05/2021
1	Infantile Hypercalcemia 05/2021
1	Congenital Hyperinsulinism 01/2021
1	Fetal Alcohol Spectrum Disorders 11/2020
1	Microcephaly 04/2020
1	Osteosarcoma (Osteogenic Sarcoma) 01/2018
1	Adrenocortical Carcinoma 01/2018
1	Cystinuria 07/2017
1	Nephrolithiasis 07/2017
1	Proteostasis Deficiencies 05/2017
1	Hydrocephalus (Hydrocephaly) 01/2017
1	Multiple Hereditary Exostoses (Hereditary Multiple Exostoses) 01/2017
1	Autoimmune Diseases (Autoimmune Disease) 01/2016
1	Human Influenza (Influenza) 01/2016
1	Virus Diseases (Viral Diseases) 01/2016
1	Dystonia (Limb Dystonia) 10/2014
1	Leukoencephalopathies 06/2014
1	Pyle disease 07/2013
1	Cartilage-hair hypoplasia 07/2013
1	Liposarcoma 05/2012
1	Endometrial Neoplasms (Endometrial Cancer) 06/2011
1	TDP-43 Proteinopathies 02/2011
1	Frontotemporal Dementia (Semantic Dementia) 07/2010
1	Neurodevelopmental Disorders 09/2009

Drug/Important Bio-Agent (IBA)

11	Proteins (Proteins, Gene)FDA Link 12/2021 - 03/2003
7	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 04/2004
4	Peptides (Polypeptides)IBA 01/2016 - 10/2006
4	Codon (Codons)IBA 03/2013 - 04/2004
4	UbiquitinIBA 05/2012 - 05/2005
3	tau Proteins (tau Protein)IBA 07/2010 - 10/2006
3	Biological ProductsIBA 01/2010 - 03/2002
3	Messenger RNA (mRNA)IBA 10/2007 - 03/2002
2	Amyloid (Amyloid Fibrils)IBA 08/2017 - 10/2006
2	Proto-Oncogene Proteins c-sis (Platelet Derived Growth Factor B)IBA 10/2014 - 06/2014
2	Bevacizumab (Avastin)FDA Link 03/2013 - 11/2012
1	Vitamin D3 24-HydroxylaseIBA 05/2021
1	KATP ChannelsIBA 01/2021
1	Metalloproteases (Metalloproteinases)IBA 11/2020
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 04/2020
1	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 01/2018
1	Presenilin-1IBA 08/2017
1	Cystine (L-Cystine)IBA 07/2017
1	Amino Acids FDA Link 07/2017
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 05/2017
1	GlycosyltransferasesIBA 01/2017
1	Neural Cell Adhesion Molecule L1 (L1 Cell Adhesion Molecule)IBA 01/2017
1	Aromatase InhibitorsIBA 11/2016
1	Hormones (Hormone)IBA 11/2016
1	Factor VIII (Coagulation Factor VIII)IBA 01/2016
1	HLA-DR15 antigenIBA 01/2016
1	Myelin Basic ProteinIBA 01/2016
1	Hemagglutinins (Hemagglutinin)IBA 01/2016
1	NucleotidesIBA 01/2016
1	HLA-DR1 Antigen (HLA DR1 Antigen)IBA 01/2016
1	2-mercaptopurineIBA 10/2015
1	Nonsense Codon (Nonsense Mutation)IBA 04/2014
1	Ribonucleases (Ribonuclease)IBA 07/2013
1	mitochondrial RNA-processing endoribonuclease (RNAse MRP)IBA 07/2013
1	Mitochondrial RNAIBA 07/2013
1	RNA (Ribonucleic Acid)IBA 07/2013
1	Calcibiotic Root Canal SealerIBA 01/2013
1	RNA-Binding Protein FUSIBA 05/2012
1	Formaldehyde (Formol)FDA Link 08/2011
1	Monoclonal AntibodiesIBA 08/2011
1	ParaffinIBA 08/2011
1	ErbB Receptors (EGF Receptor)IBA 08/2011
1	1,3- dihydroxy- 4,4,5,5- tetramethyl- 2- (4- carboxyphenyl)tetrahydroimidazole (NOR 1)IBA 06/2011
1	myosin VIIBA 07/2010
1	FilaminsIBA 07/2010
1	CAP1-6DIBA 05/2010
1	Carcinoembryonic AntigenIBA 05/2010
1	AutoantigensIBA 05/2010
1	AntigensIBA 05/2010
1	EpitopesIBA 05/2010
1	HLA-A Antigens (HLA-A)IBA 05/2010
1	HLA Antigens (Human Leukocyte Antigens)IBA 05/2010
1	HLA-A*02:01 antigenIBA 05/2010
1	ElementsIBA 01/2010

Therapy/Procedure

4	Immunotherapy 01/2016 - 09/2009
2	Therapeutics 10/2015 - 08/2011
2	Drug Therapy (Chemotherapy) 03/2013 - 11/2012
1	Transplantation 01/2016
1	Radiotherapy 05/2010
1	Adjuvant Chemotherapy 05/2010